FGFR系列蛋白

 
 
 
FGFR(Fibroblast Growth Factor Receptors),即成纤维细胞生长因子受体,一般包括FGFR1-4(也称CD331-334)四种类型。FGFR是酪氨酸酶受体家族的一支,为I型跨膜蛋白,包括胞外区、跨膜区和胞质区,通常以二聚体形式发挥作用。其中,胞外结构域包含三个Ig样区域D1(IgI)、D2(IgII)、D3(IgIII),其中D1和Acidic box组成自抑制区;D2和D3负责与配体结合(D2与细胞表面硫酸乙酰肝素结合,D3由于可变剪接有IIIb和IIIc两种形式,FGFR4中目前只发现IIIc一种亚型)。根据Ig样结构域的个数,FGFR可分为两种形式,一种是α型,含有IgI, IgII, IgIII三个区域;另一种是β型,只含IgII和IgIII。
FGFR结构(Babina IS, et al., 2017
FGFR的配体为FGF,目前已发现的人FGF有18种,除了FGF19、FGF21、FGF23是内分泌外,其余皆为旁分泌产生,其中FGF7只能与IIIb型的FGFR2结合。FGFR与FGF结合介导了RAS-RAF-MAPK、PI3K-AKT、JAK-STAT以及PLCγ等信号通路的激活传递,参与细胞生长、分化、迁移、新血管生成、调节器官发育和伤口愈合等重要生理过程。FGFR基因变异通常在肺癌、肝癌、肝内胆管癌、乳腺癌、胃癌、子宫癌及膀胱癌等实体瘤中广泛存在,并且不同癌种的FGFR突变类型及频率也存在差异。
FGF-FGFR介导的信号通路(Mason I, 2007
恺佧生物深入分析了FGFR家族蛋白的结构差异,成功制备出多种类型FGFR重组蛋白,涵盖了α和β亚型,以及IIIb和IIIc等不同形式,助力FGFR靶向药物的差异化研究!
质控示例

Human FGFR2 beta (IIIb) Protein(FGR-HM1BB)

 

Immobilized Human FGFR2 beta(IIIb) at 0.5μg/ml on the plate. Dose response curve for Anti-FGFR2 Ab., hFc Tag with the EC50 of 20.2ng/ml determined by ELISA.
Anti-FGFR2 Ab., hFc Tag can bind Human FGFR2 beta IIIb, His Tag with an affinity constant of 1.98nM as determined in a SPR assay (Biacore T200).

Human FGFR2 alpha (IIIb) Protein(FGR-HM1BD)

 

Serial dilutions of Anti-FGFR2 alpha (IIIb) Antibody were added into Human FGFR2 alpha (IIIb), His Tag : Biotinylated Human FGF10, No Tag binding reactioins.
产品列表
货号 蛋白名称 种属 标签 表达体系  
FGF-HM4RA Human FGFR1 alpha (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4RAB Biotinylated Human FGFR1 alpha (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM2RA Human FGFR2 alpha (IIIb) Protein Human C-hFc Expi293 立即询价
FGR-HM1BD Human FGFR2 alpha (IIIb) Protein Human C-His Expi293 立即询价
FGF-HM4ABB Biotinylated Human FGFR2 alpha (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGR-HM2CD Human FGFR2 alpha (IIIc) Protein Human C-His Expi293 立即询价
FGR-HM4CDB Biotinylated Human FGFR2 alpha (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGR-HM1BB Human FGFR2 beta (IIIb) Protein Human C-His Expi293 立即询价
FGR-HM4BBB Biotinylated Human FGFR2 beta (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGF-HM12D Human FGFR2 beta (IIIb) Protein Human C-His Expi293 立即询价
FGF-CM1BB Cynomolgus FGFR2 beta (IIIb) Protein Cynomolgus C-His Expi293 立即询价
FGF-MM1BB Mouse FGFR2 beta (IIIb) Protein Mouse C-His Expi293 立即询价
FGR-HM1BC Human FGFR2 beta (IIIc) Protein Human C-His Expi293 立即询价
FGR-HM4BCB Biotinylated Human FGFR2 beta (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM43B Human FGFR3 alpha (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGF-HM43BB Biotinylated Human FGFR3 alpha (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGF-HM43C Human FGFR3 alpha (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM43CB Biotinylated Human FGFR3 alpha (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4BB Human FGFR3 beta (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4BBB Biotinylated Human FGFR3 beta (IIIb) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4BC Human FGFR3 beta (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4BCB Biotinylated Human FGFR3 beta (IIIc) Protein Human C-His-Avi Expi293 立即询价
FGF-HM4R4 Human FGFR4 Protein Human C-His-Avi Expi293 立即询价
FGF-HM2BD Human FGFR2 beta (IIIb) Domain Protein Human C-hFc Expi293 立即询价
FGR-HM2BB Human FGFR2 beta (IIIb) Protein Human C-hFc Expi293 立即询价
FGF-HM2R4 Human FGFR4 Protein Human C-hFc Expi293 立即询价
FGF-HM4R4B Biotinylated Human FGFR4 Protein Human C-His-Avi Expi293 立即询价
FGF-HE001 Human FGF basic Human No Tag E.coli 立即询价
KGF-HE101 Human FGF-7/KGF Human N-His E.coli 立即询价
FGF-HE010 Human FGF10 Human No Tag E.coli 立即询价
FGF-HM621 Human FGF21 Human N-mFc-Avi Expi293 立即询价
FGF-HM121 Human FGF21 Human N-His Expi293 立即询价
FGF-HM621B Biotinylated Human FGF21 Human N-mFc-Avi Expi293 立即询价
FGF-MM121 Mouse FGF21 Mouse N-His Expi293 立即询价
KLB-HM101 Human Beta-Klotho Protein Human C-His Expi293 立即询价
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