FGF-HM4RAB-100μg / 询价
FGF-HM4RAB-500μg / 询价
FGF-HM4RAB-500μgx2 / 询价
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Biotinylated Human FGFR1 alpha (IIIc) Protein
Recombinant Biotinylated Human FGFR1 alpha (IIIc) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Arg22-Glu374.[Accession | P11362-7]
The protein has a predicted MW of 42 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-BisPAGE result.
Less than 1EU per μg by the LAL method.
> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Human FGFR1 alpha (IIIc) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human FGFR1 alpha (IIIc) is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human FGFR1 alpha (IIIc), His Tag at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-FGFR1 Anitibody, hFc Tag with the EC50 of 10.8ng/ml determined by ELISA.
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
FGF R1a; FGFR1 alpha
(1)G?Ke F , G?Ke A , Von M?Ssenhausen A , et al. Fibroblast Growth Factor Receptor 1 as a Putative Therapy Target in Colorectal Cancer[J]. Digestion, 2013, 88(3):172-181.
