货号价格

KGF-HE101-100μg / 询价

KGF-HE101-500μg / 询价

KGF-HE101-500μgx2 / 询价

Human FGF-7/KGF Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human FGF-7/KGF Protein is expressed from E.coli with His tag at the N-Terminus.
It contains Cys32-Thr194 [Accession | P21781-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 20.1 kDa same as Tris-Bis PAGE result.

纯度(Purity)

> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 0.1EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22μm filtered solution in 50mM Tris, 250mM NaCl (pH 7.5).

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Tris-Bis PAGE

Human FGF-7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human FGF-7 is greater than 95% as determined by SEC-HPLC.

SPR Data

Human FGF-7, His Tag immobilized on CM5 Chip can bind Human FGFR2 beta (IIIb) , His Tag with an affinity constant of 18.91 nM as determined in SPR assay (Biacore T200).

背景(Background)

The expression patterns of mRNAs encoding Fibroblast Growth Factor-7 (FGF-7) and its high affinity receptor suggested that FGF-7 signaling may play a role in regulating ureteric bud growth.t Results of these studies demonstrate that the developing ureteric bud and mature collecting system of FGF-7-null kidneys is markedly smaller than wild type. FGF-7 levels modulate the extent of ureteric bud growth during development and the number of nephrons that eventually form in the kidney.

分子别名(Synonyms)

FGF-7; HBGF-7; KGF; FGF7

文献(References)

(1) Qiao J, Uzzo R, Obara-Ishihara T, Degenstein L, Fuchs E, Herzlinger D. FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development. 1999 Feb;126(3):547-54. PMID: 9876183.