ILR-RM222-100μg / 询价
ILR-RM222-500μg / 询价
ILR-RM222-500μgx2 / 询价
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Rat IL-22R alpha 1 Protein
Recombinant Rat IL-22R alpha 1 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains His16-Ala228 [Accession | NP_001178798.1].
The protein has a predicted MW of 51.08 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS, 100m L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.
IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11;IL22R-alpha-1; IL22RA1
(1) Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22. Semin Immunopathol. 2010 Mar;32(1):17-31. doi: 10.1007/s00281-009-0188-x. Epub 2010 Feb 2. PMID: 20127093.
