ILR-HM5ABB-100μg / 询价
ILR-HM5ABB-500μg / 询价
ILR-HM5ABB-500μgx2 / 询价
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Biotinylated Human IL-22R alpha 1&IL-10R beta Protein
Recombinant Biotinylated Human IL-22R alpha 1&IL-10R beta Protein is expressed from HEK293 with hFc (IgG1) tag and Avi Tag at the C-Terminus of IL-22R alpha 1 and IL-10R beta.It contains His16-Thr228 (IL-22R alpha 1) and Met20-Ser220 (IL-10R beta) [Accession | Q8N6P7(IL-22R alpha 1)&Q08334(IL-10R beta)].
The protein has a predicted MW of 52.07 kDa (IL-22R alpha 1) and 48.85 kDa (IL-10R beta). Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 24 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
IL-22Rα1&IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL10 Rβ or IL20 Rβ and the respective ligands is required for signal transduction[1].
IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ;IL22R alpha 1; IL10R beta; IL22Rα1&IL10Rβ;IL-22Ra1&IL-10Rb; IL22Ra1&IL10Rb; IL-22R alpha 1&IL-10R beta; IL22R alpha 1&IL10R beta
[1] Mossner S, Kuchner M, Fazel Modares N, Knebel B, Al-Hasani H, Floss DM, Scheller J. Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130. J Biol Chem. 2020 Aug 28;295(35):12378-12397.
