ILR-HM2AB-100μg / 询价
ILR-HM2AB-500μg / 询价
ILR-HM2AB-500μgx2 / 询价
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Non-biotinylated Human IL-22R alpha 1&IL-10R beta Protein
Recombinant Human IL-22R alpha 1&IL-10R beta Protein is expressed from HEK293 with hFc (IgG1) tag and Avi Tag at the C-Terminus of IL-22R alpha 1 and IL-10R beta.It contains His16-Thr228 (IL-22R alpha 1) and Met20-Ser220 (IL-10R beta) [Accession | Q8N6P7(IL-22R alpha 1)&Q08334(IL-10R beta)].
The protein has a predicted MW of 52.07 kDa (IL-22R alpha 1) and 48.85 kDa (IL-10R beta). Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 24 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
IL-22Rα1 & IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL10 Rβ or IL20 Rβ and the respective ligands is required for signal transduction.
IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ;IL22R alpha 1; IL10R beta; IL22Rα1&IL10Rβ;IL-22Ra1&IL-10Rb; IL22Ra1&IL10Rb; IL-22R alpha 1&IL-10R beta; IL22R alpha 1&IL10R beta
Mossner S, Kuchner M, Fazel Modares N, Knebel B, Al-Hasani H, Floss DM, Scheller J. Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130. J Biol Chem. 2020 Aug 28;295(35):12378-12397.
