GDF-HM111-100μg / 询价
GDF-HM111-500μg / 询价
GDF-HM111-500μgx2 / 询价
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Human Latent GDF-11 Protein
Recombinant Human Latent GDF-11 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala25-Ser407 [Accession | O95390].
The protein has a predicted MW of 44.14 kDa. Due to glycosylation, the protein migrates to 15-20 kDa, 40-45 kDa and 50-60 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Growth differentiation factor-11 (GDF-11), also known as bone morphogenetic protein-11, belongs to the transforming growth factor-beta superfamily. GDF-11 is highly related to MSTN, plays multiple roles during embryonic development, including regulating development of the axial skeleton, kidneys, nervous system, and pancreas.
GDF11; BMP-11;
(1) Wu Z, Fang L, Yang S, Gao Y, Wang Z, Meng Q, Dang X, Sun YP, Cheng JC. GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression. Cell Commun Signal. 2022 Jun 15;20(1):89. doi: 10.1186/s12964-022-00899-z. PMID: 35705978; PMCID: PMC9202197.
(2) Lee SJ, Lehar A, Rydzik R, Youngstrom DW, Bhasin S, Liu Y, Germain-Lee EL. Functional replacement of myostatin with GDF-11 in the germline of mice. Skelet Muscle. 2022 Mar 15;12(1):7. doi: 10.1186/s13395-022-00290-z. PMID: 35287700; PMCID: PMC8922734.
