GDF-HM008B-100μg / 询价
GDF-HM008B-500μg / 询价
GDF-HM008B-500μgx2 / 询价
Biotinylated Human/Cynomolgus/Mouse/Rat GDF-8 Protein
Recombinant Biotinylated Human/Cynomolgus/Mouse/Rat GDF-8 Protein is expressed from HEK293 with Avi tag at the C-terminus.It contains Asp267-Ser375 (Human/Cynomolgus) / Asp268-Ser376 (Mouse/Rat) [Accession | O14793(Human) / Q95J86(Cynomolgus) / O08689(Mouse) / O35312(Rat)].
The protein has a predicted MW of 14.21 kDa. Due to glycosylation, the protein migrates to 15-18 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in 4mM HCL.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-β family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a furin-like protease to yield an N-terminal prodomain and a C-terminal mature, signaling domain.
Myostatin; GDF8; Mstn; GDF-8; Myostatin
Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB. Molecular characterization of latent GDF8 reveals mechanisms of activation. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E866-E875. doi: 10.1073/pnas.1714622115. Epub 2018 Jan 18. PMID: 29348202; PMCID: PMC5798348.
