GDF-HM002-100μg / 询价
GDF-HM002-500μg / 询价
GDF-HM002-500μgx2 / 询价
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Human GDF-2/BMP-9 Protein
Recombinant Human GDF-2/BMP-9 Protein is expressed from HEK293 without tag.It contains Ser320-Arg429 [Accession | Q9UK05].
The protein has a predicted MW of 12.08 kDa. Due to glycosylation, the protein migrates to 13-15 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in 4mM HCL. Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in 4mM HCL. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Bone morphogenetic proteins (BMPs) are expressed in different cell types of the human ovarian follicle and play important roles in the regulation of ovarian function. BMP-9, also known as growth differentiation factor-2 (GDF-2), belongs to the transforming growth factor-beta (TGF-β) superfamily. BMP-9 is mainly synthesized in the liver and secreted into the blood which allows it to regulate various physiological and pathological functions.
GDF-2; GDF2; BMP-9; BMP9
Fang L, Jia Q, Liu B, Yan Y, Han X, Guo Y, Cheng JC, Sun YP. BMP-9 downregulates StAR expression and progesterone production by activating both SMAD1/5/8 and SMAD2/3 signaling pathways in human granulosa-lutein cells obtained from gonadotropins induced ovarian cycles. Cell Signal. 2021 Oct;86:110089. doi: 10.1016/j.cellsig.2021.110089. Epub 2021 Jul 13. PMID: 34265413.
