FGF-HM1RA-100μg / 询价
FGF-HM1RA-500μg / 询价
FGF-HM1RA-500μgx2 / 询价
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Human FGFR1 alpha (IIIc) Protein
Recombinant Human FGFR1 alpha (IIIc) Protein is expressed from HEK293 with His tag at the C-terminus.It contains Arg22-Glu374 [Accession | P11362-7].
The protein has a predicted MW of 40.74 kDa. Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 0.1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
FGF R1a; FGFR1 alpha
(1)G?Ke F , G?Ke A , Von M?Ssenhausen A , et al. Fibroblast Growth Factor Receptor 1 as a Putative Therapy Target in Colorectal Cancer[J]. Digestion, 2013, 88(3):172-181.
