CLD-HM006B-100μg / 询价
CLD-HM006B-100μgx5 / 询价
CLD-HM006B-100μgx10 / 询价
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Biotinylated Human Claudin 6 VLP
Recombinant Biotinylated Full length Human Claudin 6 VLP is expressed from HEK293.It contains Met1-Val220 (It may have cross reaction with anti-His antibody) [Accession | P56747].
The target protein has a predicted MW of 24.5 kDa.
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Biotinylated Human Claudin 6 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human Claudin 6 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Claudin6 Antibody, mFc Tag with the EC50 of 6.5ng/ml determined by ELISA (QC Test).
Biotinylated Human Claudin 6 VLP captured on CM5 Chip via streptavidin can bind Anti-Claudin 6 Antibody with an affinity constant of 0.46 nM as determined in SPR assay (Biacore T200).
Loaded Biotinylated Human Claudin 6 VLP on Streptavidin-Biosensor can bind Anti-Claudin 6 Antibody, hFc Tag with an affinity constant of 1.46 nM as determined in BLI assay (Gator® Prime).
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively.
Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2
(1) Sugimoto K, Ichikawa-Tomikawa N, Kashiwagi K, Endo C, Tanaka S, Sawada N, Watabe T, Higashi T, Chiba H. Cell adhesion signals regulate the nuclear receptor activity. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24600-24609. doi: 10.1073/pnas.1913346116. Epub 2019 Nov 18. PMID: 31740618; PMCID: PMC6900646.
