CD8-HM18NB-100μg / 询价
CD8-HM18NB-100μgx5 / 询价
CD8-HM18NB-100μgx10 / 询价
- 关联产品
- 客服电话
- 技术支持
Biotinylated Human CD81 Nanodisc
Our Styrene-Maleic Anhydride(SMA) nanodisc platform delivers multi-pass transmembrane proteins exactly as they exist in the HEK293 cell membrane following recombinant expression— preserving their endogenous lipid environment and correct conformational states. Isolated directly from HEK293 cells via a gentle, detergent-free process, the multi-pass membrane proteins are subsequently encapsulated by SMA to ensure their stability. These uniform soluble nanoparticles eliminate extraction interferences while maintaining biological activity. Ensuring consistent performance from lot to lot, our nanodiscs provide the reliability and biological relevance essential for antibody screening and functional characterization in therapeutic antibody drug discovery and development, as assessed by SPR, BLI, ELISA, and other standard platforms.
❖ Correct structure & conformation
❖ Functional relevance ensured
❖ His-tag & biotinylation tag available
❖ Antibody screening
❖ Functional characterization(Molecular Level)
❖ Assay: SPR, BLI, ELISA
Recombinant Biotinylated Human CD81 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Tyr236 [Accession | P60033].
The protein has a predicted MW of 38.9 kDa.
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
CD81 (TAPA-1) is a member of the tetraspanin family, a large group of evolutionary conserved membrane proteins containing 4 transmembrane domains. The most distinctive feature of the tetraspanin proteins is the ability to form lateral associations with one another and to cluster dynamically with multiple cell surface receptors. Tetraspanins are capable of recruiting specific intracellular signaling enzymes, including protein kinase C, that is known to be involved in integrin phosphorylation.
TAPA-1; Tspan-28; TAPA1; TSPAN28; CVID6; S5.7
Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. PMID: 9597125.
