ALS-HE001 | 价格

ALS-HE001-100μg / 询价

ALS-HE001-500μg / 询价

ALS-HE001-500μgx2 / 询价

Human Alpha Synuclein Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human Alpha Synuclein Protein is expressed from E.coli without tag.
It contains Met1-Ala140 [Accession | P37840-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 14.5 kDa same as Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in 20mM Tris, 150mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE
Human Alpha Synuclein on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
SEC-HPLC
The purity of Human Alpha Synuclein is greater than 95% as determined by SEC-HPLC.
背景(Background)

Alpha-synuclein (α-synuclein) is a small, acidic protein containing 140 amino acids, highly expressed in the brain and primarily localized in the presynaptic terminals. It is found in high concentrations in Lewy Bodies, proteinaceous aggregates that constitute a typical histopathologic hallmark of Parkinson's disease.

分子别名(Synonyms)

Alpha-synuclein; NACP; SNCA; PARK1

文献(References)

Marino G, Calabresi P, Ghiglieri V. Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease. Handb Clin Neurol. 2022;184:153-166. doi: 10.1016/B978-0-12-819410-2.00008-4. PMID: 35034731.

Note: HPLC results always come from liquid protein, due to absorption peak interference of trehalose in lyophilized powder.