TFR-HM4ADB-100μg / 询价
TFR-HM4ADB-500μg / 询价
TFR-HM4ADB-500μgx2 / 询价
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Biotinylated Human Transferrin R/CD71 Apical Domain Protein
Recombinant Biotinylated Human Transferrin R/CD71 Apical Domain Protein is expressed from HEK293 with His tag and Avi tag at the N-terminus.It contains Lys189-Glu383 [Accession | P02786].
The protein has a predicted MW of 24.96 kDa. Due to glycosylation, the protein migrates to 32-45 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 0.1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The transferrin receptor (CD71) is known as a receptor for IgA1 on mesangial cells. The transcript and protein expression of glomerular CD71 was determined by real-time polymerase chain reaction and immunohistochemistry. Human mesangial cells (HMCs) were treated with sera from IgAN patients and expression levels of CD71 and inflammatory cytokine markers were compared according to disease status.
TR; TfR1; CD71; sTfR; T9; p90; TFRC; TFR
(1) Jhee JH, Nam BY, Park JT, Kim HW, Chang TI, Kang EW, Lim BJ, Yoo TH, Kang SW, Jeong HJ, Han SH. CD71 mesangial IgA1 receptor and the progression of IgA nephropathy. Transl Res. 2021 Apr;230:34-43. doi: 10.1016/j.trsl.2020.10.007. Epub 2020 Oct 24. PMID: 33122053.
