货号价格

ROR-HM401-100μg / 询价

ROR-HM401-500μg / 询价

ROR-HM401-1mg / 询价

Human/Cynomolgus/Rhesus macaque ROR1 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human/Cynomolgus/Rhesus macaque ROR1 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Gln30-Glu403.[Accession | Q01973-1]

分子量大小(Molecular Weight)

The protein has a predicted MW of 44.9 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC

制剂(Formulation)

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended (usually we use 1mg/ml solution for lyophilization). Dissolve the lyophilized protein in distilled water.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-20 to -80°C for 3-6 months in unopened state after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.

产品数据(Assay Data)
Tris-Bis PAGE

Human/Cynomolgus/Rhesus macaque ROR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human/Cynomolgus/Rhesus macaque ROR1 is greater than 95% as determined by SEC-HPLC.

ELISA Data

Immobilized Human/Cynomolgus/Rhesus macaque ROR1 at 1μg/ml (100μl/Well) on the plate. Dose response curve for Anti-ROR1 Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.

背景(Background)

ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are common to receptors of the Wnt family members.

分子别名(Synonyms)

ROR1; NTRKR1; dJ537F10.1

文献(References)

(1)Zhang S , Cui B , Lai H , et al. Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy[J]. Proceedings of the National Academy of Sciences, 2014, 111(48):17266-71.

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