TSP-HM201-100μg / 询价
TSP-HM201-500μg / 询价
TSP-HM201-500μgx2 / 询价
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Human TSLP Protein
Recombinant Human TSLP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Tyr29-Gln159 [Accession | Q969D9-1].
The protein has a predicted MW of 41.69 kDa. Due to furin cleavage site, the protein migrates to 38-42 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
>95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human TSLP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human TSLP is greater than 95% as determined by SEC-HPLC.
Immobilized Human TSLP, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human TSLPR, His Tag with the EC50 of 0.44 μg/ml determined by ELISA (QC Test).
Immobilized Human TSLP, hFc Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Biotinylated Anti-TSLP Antibody, hFc Tag with the EC50 of 87.0 ng/ml determined by ELISA.
Loaded Human TSLP, hFc Tag on ProA-Biosensor can bind Human TSLPR, His Tag with an affinity constant of 82.50 nM as determined in BLI assay (Gator® Prime).
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells.
thymic stromal lymphopoietin; TSLP
(1) Corren J , Parnes J R , Wang L , et al. Tezepelumab in Adults with Uncontrolled Asthma[J]. New England Journal of Medicine, 2017, 377(10):936-946.
