OSM-CM101-100μg / 询价
OSM-CM101-500μg / 询价
OSM-CM101-500μgx2 / 询价
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Cynomolgus OSMR Protein
Recombinant Cynomolgus OSMR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu28-Ser737 [Accession | A0A2K5UFW5].
The protein has a predicted MW of 82.04 kDa. Due to glycosylation, the protein migrates to 110-130 kDa based on Bis-Tris PAGE result.
>95% as determined by Bis-Tris PAGE
>95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Cynomolgus OSMR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus OSMR is greater than 95% as determined by SEC-HPLC.
Immobilized Cynomolgus OSMR, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 8.4 ng/ml determined by ELISA (QC Test).
OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ;IL-31R subunit β; IL-31R-β; OSMR β
(1) Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A. OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation. Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z. PMID: 32807793; PMCID: PMC7431428.
