OSG-HM101-100μg / 询价
OSG-HM101-500μg / 询价
OSG-HM101-500μgx2 / 询价
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Human OSMR beta-GPL fusion Protein
Recombinant Human OSMR beta-GPL fusion Protein is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Ala428 (OSMR beta) and Leu21-Glu225 (GPL) [Accession | Q99650-1(OSMR beta)&Q8NI17-1(GPL)].
The protein has a predicted MW of 75.84 kDa. Due to glycosylation, the protein migrates to 110-140 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human OSMR beta-GPL fusion Protein on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human OSMR beta-GPL fusion Protein, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA.
OSMR involvement, together with Gp130-like receptor (GPL), also known as IL-31R, in the formation of a functional IL-31 receptor complex. OSMR-GPL fusion protein was designed to contain the domains of OSMR and GPL required for high affinity IL-31 binding.
OSMR-GPL
[1] M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004 Jul;5(7):752-60.
[2] Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, Chevalier S, Gascan H. Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor. J Biol Chem. 2006 Dec 1;281(48):36673-82.
