ILR-HM323-100μg / 询价
ILR-HM323-500μg / 询价
ILR-HM323-500μgx2 / 询价
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Human IL-23R Protein
Recombinant Human IL-23R Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Gly24-Gly355 [Accession | Q5VWK5-1].
The protein has a predicted MW of 63.7 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human IL-23R is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human IL-23 alpha&IL-12 beta, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 36.4ng/ml determined by ELISA (QC Test).
Human IL-23R, mFc Tag captured on CM5 Chip via Anti-Mouse Antibody can bind Human IL-23 alpha&IL-12 beta, His-Avi Tag with an affinity constant of 11.09 nM as determined in SPR assay (Biacore T200).
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.
IBD17; IL-23 R; IL-23 receptor
Li Y, Wang H, Lu H, Hua S. Regulation of Memory T Cells by Interleukin-23. Int Arch Allergy Immunol. 2016;169(3):157-62. doi: 10.1159/000445834. Epub 2016 Apr 22. PMID: 27100864.
