ILR-HM223B-100μg / 询价
ILR-HM223B-500μg / 询价
ILR-HM223B-500μgx2 / 询价
- 关联产品
- 客服电话
- 技术支持
Biotinylated Human IL-23R Protein (Primary Amine Labeling)
Recombinant Biotinylated Human IL-23R Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the C-terminus.It contains Gly24-Gly355 [Accession | Q5VWK5-1].
The protein has a predicted MW of 64.81 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Biotinylated Human IL-23R, hFc Avi Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 42.04 nM as determined in SPR assay (Biacore T200).
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.
IBD17; IL-23 R; IL-23 receptor
Li Y, Wang H, Lu H, Hua S. Regulation of Memory T Cells by Interleukin-23. Int Arch Allergy Immunol. 2016;169(3):157-62. doi: 10.1159/000445834. Epub 2016 Apr 22. PMID: 27100864.
