DR3-HM401B-100μg / 询价
DR3-HM401B-500μg / 询价
DR3-HM401B-500μgx2 / 询价
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Biotinylated Human DR3/TNFRSF25 Protein
Recombinant Biotinylated Human DR3/TNFRSF25 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gln25-Gln199 [Accession | AAI17190.1].
The protein has a predicted MW of 26.40 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Human DR3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Immobilized Biotinylated Human DR3, His-Avi Tag at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Human TNFSF15, hFc Tag with the EC50 of 15.2ng/ml determined by ELISA (QC Test).
Death Receptor 3 (DR3), also known as TNFRSF25, TRAMP, LARD, or WSL-1, is a death-domain-containing TNF-family receptor that, like its closest paralog TNFR1, binds the adaptor molecule TRADD through its cytoplasmic death domain. TRADD recruitment endows DR3 with dual-signaling capability to activate NF−κB and MAP-kinase signaling or alternatively trigger caspase activation and programmed cell death.
APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; TNFRSF25; LARD; TR3; TRAMP; WSL-LR
Meylan F, Davidson TS, Kahle E, Kinder M, Acharya K, Jankovic D, Bundoc V, Hodges M, Shevach EM, Keane-Myers A, Wang EC, Siegel RM. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity. 2008 Jul 18;29(1):79-89. doi: 10.1016/j.immuni.2008.04.021. Epub 2008 Jun 19. PMID: 18571443; PMCID: PMC2760084.
