LIL-HM4A3-100μg / 询价
LIL-HM4A3-500μg / 询价
LIL-HM4A3-500μgx2 / 询价
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Human LILRA3/CD85e Protein
Recombinant Human LILRA3/CD85e Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly24-Glu439 [Accession | Q8N6C8].
The protein has a predicted MW of 47.9 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1EU per μg by the LAL method.
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).Normally 8% trehalose is added as protectant before lyophilization.
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human LILRA3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human LILRA is greater than 95% as determined by SEC-HPLC.
Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
CD85e; HM31; HM43; ILT6; ILT-6; LILRA3; LIR4; LIR-4HM43e3
(1)Ordó?ez, D, Sánchez, A J, Martínez-Rodríguez, J E, et al. Multiple sclerosis associates with LILRA3 deletion in Spanish patients[J]. Genes & Immunity, 2009, 10(6):579-585.
