CEA-HM103 | 价格

CEA-HM103-100μg / 询价

CEA-HM103-500μg / 询价

CEA-HM103-500μgx2 / 询价

Human CEACAM-3/CD66d Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human CEACAM-3/CD66d Protein is expressed from HEK293 with His tag at the C-terminus.
It contains Lys35-Gly155 [Accession | P40198-1].

分子量大小(Molecular Weight)

The protein has a predicted MW of 14.19 kDa. Due to glycosylation, the protein migrates to 17-27 kDa based on Bis-Tris PAGE result.

纯度(Purity)

> 95% as determined by Bis-Tris PAGE

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

重构方法(Reconstitution)

Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

存储(Storage)

-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Bis-Tris PAGE

Human CEACAM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data

Immobilized Human CEACAM-3, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human CEACAM-7, hFc Tag with the EC50 of 23.2ng/ml determined by ELISA. (QC Test)

背景(Background)

The human granulocyte-specific receptor carcinoembryonic antigen-related cell adhesion molecule (CEACAM)3 is critically involved in the opsonin-independent recognition of several bacterial pathogens. CEACAM3-mediated phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3 and is characterized by rapid stimulation of the GTPase Rac.

分子别名(Synonyms)

CEACAM3; CD66d; CGM1; CEA;

文献(References)

Schmitter T, Pils S, Sakk V, Frank R, Fischer KD, Hauck CR. The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. J Immunol. 2007 Mar 15;178(6):3797-805. doi: 10.4049/jimmunol.178.6.3797. PMID: 17339478.