货号价格

CD2-HM124V-100μg / 询价

CD2-HM124V-500μg / 询价

CD2-HM124V-500μgx2 / 询价

Human CD24 Protein-VLP

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant Human CD24 Protein-VLP is expressed from HEK293.
It contains Ser27-Gly59 [Accession | P25063-1].

分子量大小(Molecular Weight)

The target protein has a predicted MW of 5.0 kDa.

内毒素(Endotoxin)

Less than 1 EU per μg by the LAL method.

制剂(Formulation)

Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
ELISA Data

Immobilized Human CD24 VLP at 0.5 μg/ml (100 μl/Well) on the plate. Dose response curve for Anti-CD24 Antibody, hFc Tag with the EC50 of 16.4 ng/ml determined by ELISA.

背景(Background)

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers.

分子别名(Synonyms)

CD 24; CD24 molecule; CD24A; FLJ22950; FLJ43543; MGC75043

文献(References)

(1) Barkal AA, et al.CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.Nature. 2019 Jul 31. doi: 10.1038/s41586-019-1456-0.D

(2)Sun F, Wang T, Jiang J, et al. Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design[J]. Oncotarget, 2017, 8(31):51238-51252.