抑制性白细胞免疫球蛋白样受体(LILRBs)
免疫检查点蛋白和肿瘤维持因子

 
 
 
随着国内药物监管越来越开放,针对特定靶点的新药在未来可能将不会有国产和非国产之分,国内药企将迈入全球竞争时代,First-in-class将会取代Fast follow,成为药业研发的战略选择。因此,在如今越来越成熟的新药研发路径下,抗体发现好做,靶点难求,想做First-in-class,新靶点新机理将是战略选择的关键点,而抑制性白细胞免疫球蛋白样受体LILRBs将会是新机理新靶点的选择之一。
抑制性白细胞免疫球蛋白样受体(The leukocyte Ig-like receptor subfamily B LILRB)是一类一次跨膜糖蛋白,该类蛋白的胞外区有免疫球蛋白样(Ig-like)结构域,胞内区域有ITIM基序(Immunoreceptor tyrosine-based inhibitory motif 基于酪氨酸的免疫受体抑制性基序)。

抑制性白细胞免疫球蛋白样受体(LILRBs)系列

恺佧生物基于对靶点的深入了解和结构的研究,开发了一系列LILRB 家族蛋白以及domain, 配体HLA-G 蛋白的不同聚体形式,助力差异化抗体研究。
案例展示

Human LILRB2 / CD85d / ILT4 LILRB2 Domain1&2 Protein

ELISA Data

 

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SPR Data

 

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Human HLA-G Complex Tetramer, His Tag immobilized on CM5 Chip can bind Human LILRB2 Domain1&2, His Tag with an affinity constant of 6.5μM as determined in a SPR assay (Biacore T200)

Human LILRB2 / CD85d / ILT4 Protein

ELISA Data

 

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SPR Data

 

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Human LILRB2 captured on Protein A Chip can bind HLA-G Complex Tetramer, His Tag with an affinity constant of 9.2 nM as determined in SPR assay (Biacore T200).
产品列表
货号 蛋白名称 种属 标签 表达系统  
hot.png HLG-HM41C HLA-G Complex Protein Human C-His Expi293 立即询价
hot.png HLG-HM41CB Biotinylated HLA-G Complex Human C-His-Avi Expi293 立即询价
hot.png HLG-HM41CT HLA-G Complex Tetramer Human C-His Expi293 立即询价
hot.png HLG-HM41CTB Biotinylated HLA-G Complex Tetramer Human C-His-Avi Expi293 立即询价
hot.png HLG-CM41C HLA-G Complex Cynomolgus C-His Expi293 立即询价
hot.png HLG-CM41CT HLA-G Complex Tetramer Cynomolgus C-His Expi293 立即询价
hot.png HLG-RM41C HLA-G Complex Rhesus macaque C-His Expi293 立即询价
hot.png HLG-RM41CT HLA-G Complex Tetramer Rhesus macaque C-His Expi293 立即询价
hot.png HLG-HM41CTP PE labeled HLA-G Complex Tetramer Human C-His Expi293 立即询价
LIL-HM4B1 LILRB1 Human C-His Expi293 立即询价
LIL-HM4B1B Biotinylated LILRB1 Human C-His-Avi Expi293 立即询价
LIL-HM2B1 LILRB1 Human C-hFc Expi293 立即询价
LIL-HM3B1 LILRB1 Human C-mFc Expi293 立即询价
LIL-HM11D LILRB1 Domain 1&2  Human C-His Expi293 立即询价
LIL-CM1B5 LILRB1 Cynomolgus C-His Expi293 立即询价
LIL-CM1B1 LILRB1 Rhesus macaque C-His Expi293 立即询价
LIL-CM2B3 LILRB1 Rhesus macaque C-hFc Expi293 立即询价
LIL-HM4B2 LILRB2  Human C-His Expi293 立即询价
LIL-HM4B2B Biotinylated LILRB2 Human C-His-Avi Expi293 立即询价
LIL-HM2B2 LILRB2 Human C-hFc Expi293 立即询价
LIL-HM3B2 LILRB2 Human C-mFc Expi293 立即询价
LIL-HM12D LILRB2 Domain 1&2 Human C-His Expi293 立即询价
LIL-CM1B2 LILRB2 Cynomolgus C-His Expi293 立即询价
LIL-CM2B2 LILRB2 Cynomolgus C-hFc Expi293 立即询价
ANG-HM4L2 ANGPTL2 Human C-His Expi293 立即询价
ANG-HM4L2B Biotinylated ANGPTL2 Human C-His-Avi Expi293 立即询价
ANG-HM403 ANGPTL3 Human C-His Expi293 立即询价
ANG-HM403B Biotinylated ANGPTL3 Human C-His-Avi Expi293 立即询价
ANG-HM1L4 ANGPTL4 Human N-His Expi293 立即询价
ANG-MM104 ANGPTL4 Mouse N-His Expi293 立即询价
LIL-HM4B3 LILRB3 Human C-His Expi293 立即询价
LIL-HM4B3B Biotinylated LILRB3 Human C-His-Avi Expi293 立即询价
LIL-HM4B4 LILRB4 Human C-His Expi293 立即询价
LIL-HM4B4B Biotinylated LILRB4 Human C-His-Avi Expi293 立即询价
LIL-HM2B4 LILRB4 Human C-hFc Expi293 立即询价
LIL-MM1B4 LILRB4 Mouse C-His Expi293 立即询价
LIL-CM1B4 LILRB4 Cynomolgus C-His Expi293 立即询价
APO-HM101 APOE Human N-His Expi293 立即询价
APO-HM202 APOE (Cys130Arg) Human N-hFc Expi293 立即询价
APO-MM102 APOE Mouse C-His Expi293 立即询价
APO-MM202 APOE Mouse C-hFc Expi293 立即询价
LIL-HM4B5 LILRB5 Human C-His Expi293 立即询价
LIL-HM4B5B Biotinylated LILRB5 Human C-His-Avi Expi293 立即询价
LIL-HM4A1 LILRA1 Human C-His Expi293 立即询价
LIL-HM4A1B Biotinylated LILRA1 Human C-His-Avi Expi293 立即询价
LIL-HM4A2 LILRA2 Human C-His Expi293 立即询价
LIL-HM4A2B Biotinylated LILRA2 Human C-His-Avi Expi293 立即询价
LIL-HM4A3 LILRA3 Human C-His Expi293 立即询价
LIL-HM4A3B Biotinylated LILRA3 Human C-His-Avi Expi293 立即询价
LIL-HM4A4 LILRA4 Human C-His Expi293 立即询价
LIL-HM4A4B Biotinylated LILRA4 Human C-His-Avi Expi293 立即询价
LIL-CM1A4 LILRA4 Cynomolgus C-His Expi293 立即询价
LIL-HM4A5 LILRA5 Human C-His Expi293 立即询价
LIL-HM4A5B Biotinylated LILRA5 Human C-His-Avi Expi293 立即询价
LIL-HM4A6 LILRA6 Human C-His Expi293 立即询价
LIL-HM4A6B Biotinylated LILRA6 Human C-His-Avi Expi293 立即询价
恺佧生物科技(上海)有限公司
电话:400-614-0008
地址:上海市浦江高科技园新骏环路188号8A区四楼
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