抑制性白细胞免疫球蛋白样受体(LILRBs)
免疫检查点蛋白和肿瘤维持因子

随着国内药物监管越来越开放,针对特定靶点的新药在未来可能将不会有国产和非国产之分,国内药企将迈入全球竞争时代,First-in-class将会取代Fast follow,成为药业研发的战略选择。因此,在如今越来越成熟的新药研发路径下,抗体发现好做,靶点难求,想做First-in-class,新靶点新机理将是战略选择的关键点,而抑制性白细胞免疫球蛋白样受体LILRBs将会是新机理新靶点的选择之一。
抑制性白细胞免疫球蛋白样受体(The leukocyte Ig-like receptor subfamily B LILRB)是一类一次跨膜糖蛋白,该类蛋白的胞外区有免疫球蛋白样(Ig-like)结构域,胞内区域有ITIM基序(Immunoreceptor tyrosine-based inhibitory motif 基于酪氨酸的免疫受体抑制性基序)。

抑制性白细胞免疫球蛋白样受体(LILRBs)系列

恺佧生物基于对靶点的深入了解和结构的研究,开发了一系列LILRB 家族蛋白以及domain, 配体HLA-G 蛋白的不同聚体形式,助力差异化抗体研究。
案例展示

Human LILRB2 / CD85d / ILT4 LILRB2 Domain1&2 Protein

ELISA Data

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SPR Data

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Human HLA-G Complex Tetramer, His Tag immobilized on CM5 Chip can bind Human LILRB2 Domain1&2, His Tag with an affinity constant of 6.5μM as determined in a SPR assay (Biacore T200)

Human LILRB2 / CD85d / ILT4 Protein

ELISA Data

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SPR Data

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Human LILRB2 captured on Protein A Chip can bind HLA-G Complex Tetramer, His Tag with an affinity constant of 9.2 nM as determined in SPR assay (Biacore T200).
产品列表
货号 名称 种属 标签 表达体系
LIL-HM4A1 Human LILRA1/CD85i/LIR-6 Protein Human C-His-Avi Expi293 立即询价
LIL-HM4A2 Human LILRA2/CD85h/ILT1 Protein Human C-His-Avi Expi293 立即询价
LIL-HM4A3 Human LILRA3/CD85e Protein Human C-His-Avi Expi293 立即询价
LIL-HM4A4 Human LILRA4/CD85g Protein Human C-His-Avi Expi293 立即询价
LIL-CM1A4 Cynomolgus LILRA4/CD85g Protein Cynomolgus C-His Expi293 立即询价
LIL-HM4A5 Human LILRA5/CD85f/ILT11 Protein Human C-His-Avi Expi293 立即询价
LIL-HM4A6 Human LILRA6/CD85b/ILT8 Protein Human C-His-Avi Expi293 立即询价
LIL-HM4B1 Human LILRB1/CD85j/ILT2 Protein Human C-His-Avi Expi293 立即询价
LIL-HM2B1 Human LILRB1/CD85j/ILT2 Protein Human C-hFc Expi293 立即询价
LIL-CM1B1 Rhesus macaque LILRB1/CD85j/ILT2 Protein Rhesus macaque C-His Expi293 立即询价
LIL-HM11D Human LILRB1/CD85j/ILT2 Domain1&2 Protein Human C-His Expi293 立即询价
LIL-HM4B2 Human LILRB2/CD85d/ILT4 Protein Human C-His-Avi Expi293 立即询价
LIL-HM2B2 Human LILRB2/CD85d/ILT4 Protein Human C-hFc Expi293 立即询价
LIL-HM12D Human LILRB2/CD85d/ILT4 Domain1&2 Protein Human C-His Expi293 立即询价
LIL-CM1B2 Cynomolgus LILRB2/CD85d/ILT4 Protein Cynomolgus C-His Expi293 立即询价
LIL-HM4B3 Human LILRB3/CD85a/ILT5 Protein Human C-His-Avi Expi293 立即询价
LIL-HM4B4 Human LILRB4/CD85k/ILT3 Protein Human C-His-Avi Expi293 立即询价
LIL-HM2B4 Human LILRB4/CD85k/ILT3 Protein Human C-hFc Expi293 立即询价
LIL-MM1B4 Mouse LILRB4/CD85k/ILT3 Protein Mouse C-His Expi293 立即询价
LIL-CM1B4 Cynomolgus LILRB4/CD85k/ILT3 Protein Cynomolgus C-His Expi293 立即询价
LIL-HM4B5 Human LILRB5/CD85c/LIR-8 Protein Human C-His-Avi Expi293 立即询价
ANG-HM4L2 Human ANGPTL2/Angiopoietin-like 2 Protein Human C-His-Avi Expi293 立即询价
ANG-HM403 Human ANGPTL3/Angiopoietin-like 3 Protein Human C-His-Avi Expi293 立即询价
ANG-HM1L4 Human ANGPTL4/Angiopoietin-like 4 Protein Human N-His Expi293 立即询价
ANG-HM1L4 Human ANGPTL4/Angiopoietin-like 4 Protein Human N-His Expi293 立即询价
hot.pngHLG-HE41F Human HLA-G Free Heavy Chain Protein Human C-His-Avi E.coli 立即询价
hot.pngHLG-HM41C Human HLA-G Complex Protein Human C-His-Avi Expi293 立即询价
hot.pngHLG-HM41CB Biotinylated Human HLA-G Complex Protein Human C-His-Avi Expi293 立即询价
hot.pngHLG-HM41CT Human HLA-G Complex Tetramer Protein Human C-His-Avi Expi293 立即询价
hot.pngHLG-HM41CTB Biotinylated Human HLA-G Complex Tetramer Protein Human C-His-Avi Expi293 立即询价
hot.pngHLG-RM41CT Rhesus macaque HLA-G Complex Tetramer Protein Rhesus macaque C-His-Avi Expi293 立即询价
hot.pngHLG-CM41CT Cynomolgus HLA-G Complex Tetramer Protein Cynomolgus C-His-Avi Expi293 立即询价
恺佧生物科技(上海)有限公司
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